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Ionis Pharmaceuticals, Inc. (IONS) short interest & options flow

NASDAQ

IONS is the most pressured name among its closest biotech peers right now. Short interest has climbed to 13.2% of free float, a level that places it well above correlated names such as ARWR at mid-single digits and NTLA, where positioning is similarly elevated but price damage has been shallower. The stock lost 9.4% over the past week, roughly three…

Latest pulse22 Oct 2026

IONS BMO Capital upgrades to Outperform, raises PT to $66 from $54, implying 49% upside from $44.27 close. Consensus target now $82.91.

$28.19-9.06% 1d-30.26% 1w-37.74% 1mClose: 10 Nov 2026
Short interest % of float
High
Live SI on ORTEX →
Cost to borrow
Low
Live CTB on ORTEX →
Availability
High
Live availability on ORTEX →
Market cap
$4.62B
Next earnings
17 Feb 2027
See the full picture on ORTEX →Live short interest, options flow, signals, 13F filings, and more.

Key data as of 11 Nov 2026

ORTEX chart of Ionis Pharmaceuticals, Inc. (IONS) share price and short interest (% of free float), six months to November 10, 2026

Latest signals on IONS

  • Analyst

    IONS BMO Capital upgrades to Outperform, raises PT to $66 from $54, implying 49% upside from $44.27 close. Consensus target now $82.91.

    2 Analyst updates in 30 days

  • Alt Data

    IONS retail attention hits 5.4 standard deviations above its own 90-day history, per Wikipedia views and ORTEX stock page data, signaling outsized interest as of October 19.

IONS news and analysis

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Trader NoteIONS

IONS Shorts Jump 21% as Analysts Slash Targets

Ionis Pharmaceuticals heads into this week's earnings report with short interest at an 11-month high and the analyst community in near-uniform target-cutting mode — a combination that frames today's results as a…

1 min read

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