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SY

Spyre Therapeutics, Inc. (SYRE) short interest & options flow

NASDAQ

Short sellers have built a substantial position in SYRE ahead of Thursday's quarterly results. Around 16.2% of Spyre Therapeutics' free float is currently sold short, a level that has held remarkably steady over the past month, drifting only 0.6% higher across October. The past week saw a modest 3.2% reduction in shares short, though the absolute count remains near 12.5 million…

Latest pulse23 Jun 2026

SYRE put/call ratio crashes to 0.27, lowest in 52 weeks, as bullish options flow overwhelms bearish bets amid 35% monthly surge.

$99.27+3.94% 1d+0.23% 1w+6.52% 1mClose: 3 Nov 2026
Short interest % of float
High
Live SI on ORTEX →
Cost to borrow
Low
Live CTB on ORTEX →
Market cap
$9.28B
Next earnings
6 Nov 2026
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Key data as of 4 Nov 2026

ORTEX chart of Spyre Therapeutics, Inc. (SYRE) share price and short interest (% of free float), six months to November 3, 2026

SYRE news and analysis

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