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SY

Spyre Therapeutics, Inc. (SYRE) short interest & options flow

NASDAQ

Spyre Therapeutics reports Thursday with a clinical-stage IBD pipeline, a substantial short position that has barely moved all month, and a named activist holding nearly 10% of the company. Short sellers have committed to this name and have not flinched. Short interest holds at 16.2% of the free float, roughly 12.6 million shares, a level that has drifted only 0.7% higher across…

Latest pulse23 Jun 2026

SYRE put/call ratio crashes to 0.27, lowest in 52 weeks, as bullish options flow overwhelms bearish bets amid 35% monthly surge.

$104.48-4.15% 1d+5.25% 1w+21.93% 1mClose: 10 Nov 2026
Short interest % of float
High
Live SI on ORTEX →
Cost to borrow
Low
Live CTB on ORTEX →
Market cap
$9.92B
Next earnings
19 Feb 2027
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Key data as of 11 Nov 2026

ORTEX chart of Spyre Therapeutics, Inc. (SYRE) share price and short interest (% of free float), six months to November 10, 2026

SYRE news and analysis

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